Glutathione transferases in human nasal mucosa
โ Scribed by A. Aceto; C. Ilio; S. Angelucci; V. Longo; P. G. Gervasi; G. Federici
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 602 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0340-5761
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๐ SIMILAR VOLUMES
Qualitative and quantitative changes in glutathione S-transferase (GSH-T) were studied in human hepatocellular carcinoma. GSH-T specific activity (mumoles per min per mg protein) was variably reduced in hepatocellular carcinoma. Similar changes were seen in "cationic" GSH-T (ligandin) concentration
Gene codings for glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) are polymorphic in humans with null genotypes present in approximately 20 and 50%, respectively. A significant excess of homozygous null GSTT1 and GSTM1 genotypes has been demonstrated among individuals with certain types of cancer