Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers
β Scribed by Kadouri, L; Kote-Jarai, Z; Hubert, A; Baras, M; Abeliovich, D; Hamburger, T; Peretz, T; Eeles, R A
- Book ID
- 121785359
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 118 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0007-0920
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## Abstract The aim of this study was to investigate associations between genetic variability in specific Glutathione __S__βtransferases (__GST__) genes (__GSTM1__, __GSTT1__ and __GSTP1__) and susceptibility to breast cancer. Genotypes of blood specimen DNA were determined for 65 women with incide
Glutathione S-transferases (GSTs) belong to a superfamily of detoxification enzymes that provide critical defences against a large variety of chemical carcinogens and environmental toxicants. GSTs are present in most epithelial tissues of the human gastrointestinal tract. We investigated association