Glutathione S-transferase isoenzyme profile in non-tumor and tumor human kidney tissue
✍ Scribed by Tatjana Simić; Jasmina Mimić-Oka; Katarina Ille; Dejan Dragičević; Ana Savić-Radojević
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 325 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0724-4983
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Glutathione S-transferase (GST) was investigated with benzo(a)pyrene-4,5-oxide (BPO) as substrate in tissue specimens from 26 fetal and 27 adult livers and 27 placentas. The average (\_ SEM) of GST activity in the cytosol was 1.80\_ 0.18 (fetal liver), 3.05 \_\_\_ 0.30 (adult liver) and 1.18 + 0.07
We have studied the levels of glutathione S-transferase in drug-resistant and -sensitive human tumor cell lines to examine a possible involvement of glutathione S-transferase (GST) in multidrug resistance mechanisms. No increase in the activity of glutathione S-transferase was detected in myelogenou