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Glutathione S-transferase genotypes in systemic sclerosis and their association with clinical manifestations in early disease

โœ Scribed by Tew, M B; Reveille, J D; Arnett, F C; Friedman, A W; McNearney, T; Fischbach, M; Ahn, C; Tan, F K


Book ID
110037297
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
94 KB
Volume
2
Category
Article
ISSN
1466-4879

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Glutathione-S-transferase genotypes and
โœ Gabriele Stocco; Stefano Martelossi; Arrigo Barabino; Giuliana Decorti; Fiora Ba ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 123 KB ๐Ÿ‘ 2 views

## Background: Adverse drug reactions to azathioprine, the prodrug of 6-mercaptopurine, occur in 15%-38% of patients and the majority are not explained by thiopurine-s-methyltransferase (tpmt) deficiency. azathioprine is known to induce glutathione depletion and consumption of glutathione is greate