Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor α toxicity
✍ Scribed by Yang Xu; Brett E. Jones; David S. Neufeld; Mark J. Czaja
- Book ID
- 118520054
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 185 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
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## Abstract High concentrations of tumor necrosis factor α (TNFα) are cytotoxic to cultured hepatocytes. Impairment of energy metabolism and generation of an intracellular oxidant stress are important events in the pathogenesis of this toxicity (6). In the present study, we have examined the role o
The sensitization of hepatocytes to cell death from tumor necrosis factor α (TNFα) underlies many forms of hepatic injury, including that from toxins. Critical for hepatocyte resistance to TNFα toxicity is activation of nuclear factor κB (NF-κB) signaling, which prevents TNFα-induced death by the up