Glutathione in liver diseases and hepatotoxicity
โ Scribed by Liyun Yuan; Neil Kaplowitz
- Book ID
- 116727974
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 466 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0098-2997
No coin nor oath required. For personal study only.
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Experimental models for halothane hepatotoxicity require microsomal enzyme induction by phenobarbital or triiodo-thyronine pretreatment and hypoxic conditions. The role of GSH in the metabolism of halothane, however, is still unclear. We therefore pretreated male rats with phorone to deplete hepatic
The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33%