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Glutathione depletion is involved in the inhibition of procollagen α1(I) mRNA levels caused by TNF-α on hepatic stellate cells

✍ Scribed by Marta Varela-Rey; Lorena Fontán-Gabás; Patricia Blanco; María J. López-Zabalza; María J. Iraburu

Book ID: 116397854
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 196 KB
Volume: 37
Category: Article
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2007.03.013

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Oxidative stress plays a key role in liver fibrosis. Both inflammatory cells and activated Kupffer cells produce H 2 O 2 , an oxidant involved in the activation of hepatic stellate cells (HSC). Increased production of reactive oxygen intermediates (ROIs) in fibrotic livers is associated in part with