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Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions

✍ Scribed by M.A. Tirmenstein; F.A. Nicholls-Grzemski; J.-G. Zhang; M.W. Fariss


Book ID
114008572
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
175 KB
Volume
127
Category
Article
ISSN
0009-2797

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We have previously reported that transforming growth factor-beta (TGF-beta) induces apoptosis in fetal hepatocytes in primary culture. This effect was found to be associated with an increase in intracellular reactive oxygen species (ROS) and a lowering of total cellular reduced glutathione (GSH). In