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Glutathione depletion and cytotoxicity of buthionine sulphoximine and SR2508 in rodent and human cells

โœ Scribed by C.Clifton Ling; Rosemary S.L. Wong; Redempto D. Basas

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
713 KB
Volume
18
Category
Article
ISSN
0360-3016

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Cytotoxic effects of glutathione synthes
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells
โœ Robert T. Dorr; James D. Liddil; Michelle J. Soble ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer US ๐ŸŒ English โš– 601 KB

The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226