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Glutathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation

✍ Scribed by Yuji Saito; Takuhiro Hotta; Takasi Mikami; Kaoru Kurisu; Kenji Yamada; Katuzou Kiya; Keiichi Kawamoto; Tohru Uozumi; Yosihiro Nakada

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 543 KB
Volume: 48
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910480612

No coin nor oath required. For personal study only.

✦ Synopsis

Three ACNU-resistant sublines (Ri, R, and Rid. from rat glioma 9L cells showed cross-resistance to vinblastine, adriamycin, and VP-16. Among these, the R, subline also acquired radioresistance under aerobic conditions. Total glutathione levels in these sublines were elevated 2-to 3-fold. Treatment of the cells with BSO, a specific inhibitor of GSH synthesis, resulted in decreased intracellular total glutathione levels in all 4 cell lines to about 10% of control levels. However, sensitivity to radiation or to chemicals did not change accordingly. Treatment of 9L cells with OTZ, a precursor of cysteine, resulted in a rise in intracellular GSH levels but it did not correlate with sensitivity to X-ray or to ACNU. These results suggest that, in terms of cellular sensitivity to radiation or ACNU, total glutathione level alone cannot serve as a predictive indicator.

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