Glutathione: a key component of the cytoplasmic labile iron pool

Increased IRP1 and IRP2 RNA binding acti

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

✍ Cindy N. Roy; Kenneth P. Blemings; Kathryn M. Deck; Paige S. Davies; Emily L. An 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

## Abstract Iron regulatory proteins (IRPs), the cytosolic proteins involved in the maintenance of cellular iron homeostasis, bind to stem loop structures found in the mRNA of key proteins involved iron uptake, storage, and metabolism and regulate the expression of these proteins in response to cha