Glutaraldehyde-containing dentin bonding agents are mutagens in mammalian cellsin vitro
✍ Scribed by Schweikl, H. ;Schmalz, G.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 42 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
The mutagenic potential of glutaraldehyde-con-materials. There was a moderate decrease of the number taining dentin bonding agents was shown in previous studies of surviving cells immediately after the end of exposure. using a bacterial gene mutation assay, the Ames test. How-Mutagenicity at the hprt locus in V79 cells was found with ever, current strategies of genotoxicity testing and regulatory all materials tested, and the increases in the absolute numbers requirements for the biological evaluation of medical devices of mutants were dose dependent. The mutant frequencies recommend a battery of tests that indicate induced mutations were about 15-(Syntac adhesive and Gluma 3) to 20-fold in prokaryotic and eukaryotic cells. Accordingly, the mutage-(Prisma UB3 adhesive) higher than solvent control values. nicity of three glutaraldehyde-containing bonding agents Since other substances than glutaraldehyde may be responsi-(Syntac adhesive, Prisma Universal Bond 3 adhesive, and ble for the mutagenic effects in mammalian cells in this study, Gluma 3) was investigated using a quantitative mammalian work is currently in progress to identify the individual mutacell gene mutation assay (V79/HPRT test) in the present genic compounds of dentin adhesives and related composite investigation. The materials were extracted in dimethyl sulf-materials.