Glutamine synthetase in liver and brain tissues of the holocephalan,Hydrolagus colliei
β Scribed by Ritter, Nadine M. ;Smith, Darwin D. ;Campbell, James W.
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 616 KB
- Volume
- 243
- Category
- Article
- ISSN
- 0022-104X
No coin nor oath required. For personal study only.
β¦ Synopsis
Glutamine synthetase was shown to be mitochondrial in liver tissue and cytosolic in brain tissue of the holocephalan Hydrolagus colliei. The liver mitochondrial form has an M, approximately 1,500 larger than the brain cytosolic form, so the two represent compartmental isozymes. Similar isozymes have been shown to be present in elasmobranchs, and their Occurrence in holocephalans suggests the two groups share a common ancestry.
π SIMILAR VOLUMES
In a recent study in HEPATOLOGY, Werth et al. 1 reported that STAT5 is a transcription factor, which binds to a section of the upstream regulatory region of the glutamine synthetase (GS) gene that, in transfection experiments, enhances reporter-gene expression. The next obvious step to further devel