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Glutamine and glutathione counteract the inhibitory effects of mediators of sepsis in neonatal hepatocytes

✍ Scribed by Ramesh Babu; Simon Eaton; David P. Drake; Lewis Spitz; Agostino Pierro

Book ID
117826931
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
67 KB
Volume
36
Category
Article
ISSN
0022-3468

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To assess the role of insulin action and inaction in the liver, immortalized hepatocyte cell lines have been generated from insulin receptor substrate (IRS)-2 ؊/؊ and wild-type mice. Using this model, we have recently demonstrated that the lack of IRS-2 in neonatal hepatocytes resulted in insulin re