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Glutamate release inhibition ineffective in Levodopa-induced motor complications

✍ Scribed by William Bara-Jimenez; Tzvetelina D. Dimitrova; Abdullah Sherzai; Murat Aksu; Thomas N. Chase

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 54 KB
Volume: 21
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20976

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✦ Synopsis

Abstract

Reported benefits of various glutamatergic receptor antagonists in Parkinson's disease (PD) prompted an evaluation of the antidyskinetic effect of a putative glutamate release inhibitor in 15 moderately advanced patients. In a 3‐week, double‐blind, proof‐of‐concept study, riluzole (200 mg/day) failed to alter parkinsonian or levodopa‐induced motor complication severity. Opposing effects of a generalized inhibition of glutamate‐mediated synaptic transmission may limit the usefulness of this approach to treat PD. © 2006 Movement Disorder Society

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## Abstract Brain samples from 14 Parkinson's disease patients, 10 of whom developed motor complications (dyskinesias and/or wearing‐off) on dopaminomimetic therapy, and 11 controls were analyzed. Striatal 3β‐(4‐^125^I‐iodophenyl)tropane‐2β‐carboxylic acid isopropyl ester ([^125^I]RTI‐121) ‐specifi