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Glutamate receptors localize postsynaptically at neuromuscular junctions in mice

✍ Scribed by Tessily A. Mays; Jamie L. Sanford; Toshihiko Hanada; Athar H. Chishti; Jill A. Rafael-Fortney

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
766 KB
Volume
39
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

Dlg (Discs Large) is a multidomain protein that interacts with glutamate receptors and potassium channels at Drosophila neuromuscular junctions (NMJs) and at mammalian central nervous system synapses. Dlg also localizes postsynaptically at cholinergic mammalian NMJs. We show here that α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐proprionate (AMPA) receptor subunits, together with glutamate, are present at the mammalian NMJ. Both AMPA and NMDA (N‐methyl‐D‐aspartate) glutamate receptor subunits display overlapping postsynaptic localization patterns with Dlg at all NMJs examined in normal mice. Kir2 potassium channels also localize with Dlg and glutamate receptors at this synapse. Localization of the components of a glutamatergic system suggests novel mechanisms at mammalian neuromuscular synapses. Muscle Nerve 39: 343–349, 2009

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