Glutamate neurotransmission during acute hepatic failure and acute hyperammonemia
โ Scribed by da Knegt, RJ; Schalm, SW; van der Rijt, CCD; Kornhuber, J; Riederer, P
- Book ID
- 122735915
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 84 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0168-8278
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๐ SIMILAR VOLUMES
Abbreviations: HE, hepatic encephalopathy; NMDA, N-methyl-d-aspartate; AMPA, apartments. Evidence suggesting that neuron-astrocytic amino-3-hydro-5-methyl-4-isoxazole-propionic acid; KA, kainate. trafficking of glutamate is altered in HE includes the find-
Abnormalities in glutamate metabolism and glutamatergic neurotransmission appear to play a major role in the pathogenesis of hyperammonemia and hepatic encephalopathy. Astrocytes may be involved in these derangements as ammonia has been shown to impair the ability of these cells to take up glutamate