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Glutamate neurotransmission during acute hepatic failure and acute hyperammonemia

โœ Scribed by da Knegt, RJ; Schalm, SW; van der Rijt, CCD; Kornhuber, J; Riederer, P


Book ID
122735915
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
84 KB
Volume
13
Category
Article
ISSN
0168-8278

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Abnormalities in glutamate metabolism and glutamatergic neurotransmission appear to play a major role in the pathogenesis of hyperammonemia and hepatic encephalopathy. Astrocytes may be involved in these derangements as ammonia has been shown to impair the ability of these cells to take up glutamate