Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line
β Scribed by William R. Schelman; Robert D. Andres; Kimberly J. Sipe; Evan Kang; James A. Weyhenmeyer
- Book ID
- 116753119
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 376 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0169-328X
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## Abstract Secreted phospholipases A~2~ (sPLA~2~s) modulate neuronal survival and neurotransmitter release. Here we show that sPLA~2~ (group III) synergistically increases glutamateβinduced cell death and intracellular calcium ([Ca^2+^]~i~) in cultured primary cortical and hippocampal neurons. Whe
Bcl-2 over-expression has been shown to inhibit apoptosis induced by a variety of stimuli, whereas a predominance of Baxa to Bcl-2 accelerates apoptosis upon apoptotic stimuli. We sought to study the relevance of these apoptotic regulating gene products in leukaemia. In a panel of leukaemia and lymp