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Glutamate in schizophrenics and healthy controls

✍ Scribed by Wagner F. Gattaz; Daher Gattaz; Helmut Beckmann

Book ID
104731587
Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
269 KB
Volume
231
Category
Article
ISSN
1433-8491

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✦ Synopsis

Cerebrospinal fluid (CSF) glutamate levels were measured in 28 paranoid schizophrenic patients and 15 healthy individuals. From the 28 patients 15 were treated with neuroleptic drugs and 13 did not take any drugs. No significant difference was found between glutamate in patients without neuroleptics and controls. However, CSF glutamate was significantly higher in patients taking neuroleptics than in controls (P less than 0.001) or in patients without neuroleptics (P less than 0.01). This and other data from the literature indicate that enhanced levels of cerebral glutamate may be significant for the antipsychotic efficacy of neuroleptic drugs.

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Phenylethylamine and phenylacetic acid i
Phenylethylamine and phenylacetic acid in CSF of schizophrenics and healthy controls
✍ Helmut Beckmann; Gavin P. Reynolds; Merton Sandler; Peter Waldmeier; Joachim Lau πŸ“‚ Article πŸ“… 1982 πŸ› Springer-Verlag 🌐 English βš– 509 KB

Phenylethylamine (PEA) is an endogenous substance with amphetamine-like stimulant properties. On the basis of this ability an abnormal brain PEA metabolism has been proposed as an etiological factor in some forms of schizophrenia. In the present study 28 schizophrenic patients and 15 healthy control