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Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

✍ Scribed by Michael J Marino; P Jeffrey Conn

Book ID
116383405
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
132 KB
Volume
6
Category
Article
ISSN
1471-4892

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Conformationally Constrained Analogues ofL-Glutamate as Subtype-Selective Modulators of Metabotropic Glutamate Receptors
✍ Dawei Ma πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 354 KB

L-Glutamate, a major neurotransmitter in excitatory synaptic pathways of the mammalian central nervous system (CNS)(1), plays an important role in many integrative brain functions (1-4). Glutamate receptors have been classified into two distinctive groups termed ionotropic and metabotropic receptors