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Glutamate activation of Oct-2 in cultured chick Bergmann glia cells: Involvement of NFκB

✍ Scribed by J. Alfredo Méndez; Esther López-Bayghen; Arturo Ortega

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
599 KB
Volume
81
Category
Article
ISSN
0360-4012

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✦ Synopsis

del Instituto Polite ´cnico Nacional, Me ´xico Glutamate, the major excitatory neurotransmitter in the central nervous system, is critically involved in gene expression regulation at the transcriptional and translational levels. Its activity through ionotropic as well as metabotropic receptors modifies the protein repertoire in neurons and glial cells. In avian cerebellar Bergmann glia cells, glutamate receptors trigger a diverse array of signaling cascades that include activity-dependent transcription factors such as the activator protein-1, the cAMP response-element binding protein, and Oct-2. We analyze the upstream regulatory elements involved in Oct-2 activation. Our results demonstrate that Ca 2+ influx, protein kinase C, phosphatidylinositol-3 kinase, Src, and nuclear factor (NF)kB are involved in this signaling pathway. Our findings link a-amino-3-hydroxy-5methylisoxazole-4-propionate (AMPA) receptor activation to a negative phase of chkbp gene regulation, controlled by NFkB. V

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