Glutamat- und GABA-Konzentration in Gehirn und Liquor Cerebrospinalis von Ratten unter Behandlung mit Phosphatidylcholin
✍ Scribed by D. Claus; J. S. Kim; J. C. Aschoff; H. H. Kornhuber
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 365 KB
- Volume
- 232
- Category
- Article
- ISSN
- 1433-8491
No coin nor oath required. For personal study only.
✦ Synopsis
Phosphatidylcholine increases CNS concentrations of acetylcholine. In rats we investigated whether or not phosphatidylcholine also influences the neurotransmitters glutamate and GABA. In 17 rats 1.5 gram/kg Lethicon perorally was administered daily for 2 weeks, 15 rats served as controls. In tissue from frontal cortex, striatum, substantia nigra, cerebellar cortex no significant differences between treated and untreated animals were found in glutamate or GABA concentrations. A central nervous interaction between the cholinergic system and the neurotransmitters glutamate and GABA, therefore, could not be demonstrated after 2 weeks of phosphatidylcholine intake.