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Glucuronyl transferase and glycogen deficiency in liver of Gunn rats

✍ Scribed by Elias Halac Jr.; Stuart Frank

Book ID
118847331
Publisher
Elsevier Science
Year
1960
Tongue
English
Weight
192 KB
Volume
2
Category
Article
ISSN
0006-291X

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πŸ“œ SIMILAR VOLUMES

Enhanced acetaminophen toxicity in rats
Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency
✍ Sonia M. F. de Morais; Dr. Peter G. Wells πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 542 KB

Glucuronidation is the major pathway for elimination of acetaminophen, diverting it from the toxifying pathway catalyzed by cytochromes P-450. A genetic deficiency in bilirubin UDP-glucuronyl transferase may predispose humans and animals to the toxicity of drugs that are extensively glucuronidated,