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Glucuronidation of 4-methylumbelliferone and 4-hydroxybiphenyl and in vitro induction of UDP-glucuronosyltransferase 2B12-mRNA in precision-cut rat liver slices

✍ Scribed by Klaus Pissowotzki; Reinhild Glöckner; Dieter Müller


Book ID
114493881
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
64 KB
Volume
54
Category
Article
ISSN
0940-2993

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The inhibitory potencies of non-steroidal anti-inflammatory drugs (NSAIDs) on UDP-glucuronosyltransferase (UGT) 1A9 activity were investigated in recombinant human UGT1A9 using 4-methylumbelliferone (4-MU) as a substrate for glucuronidation. 4-MU glucuronidation (4-MUG) showed Michaelis-Menten kinet