Glucosylceramide synthase and apoptosis
β Scribed by Richard J. Bleicher; Myles C. Cabot
- Book ID
- 117772258
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 165 KB
- Volume
- 1585
- Category
- Article
- ISSN
- 1388-1981
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As a strategy to enhance tumor cell sensitivity to vincristine, we tested whether modulation of sphingolipid metabolism would alter vincristine cytotoxicity since this is linked to accumulation of the intermediate metabolite, ceramide. We blocked ceramide metabolism in a series of variably vincristi
## Abstract Glycosphingolipids are organizational building blocks of plasma membranes that participate in key cellular functions, such as signaling and cellβtoβcell interactions. Glucosylceramide synthaseβencoded by the __Ugcg__ geneβcontrols the first committed step in the major pathway of glycosp