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Glucose transporter-1 gene expression is associated with pancreatic cancer invasiveness and MMP-2 activity

✍ Scribed by Hiromichi Ito; Mark Duxbury; Michael J. Zinner; Stanley W. Ashley; Edward E. Whang


Book ID
113919838
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
305 KB
Volume
136
Category
Article
ISSN
0039-6060

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t