Glucose-sensing Receptor in Pancreatic Beta-cells

✍ Scribed by Itaru Kojima

• Publisher: Springer Singapore
• Year: 2018
• Tongue: English
• Leaves: 73
• Edition: 1st ed.
• Category: Library

✦ Synopsis

Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.”

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.

The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”.

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.

✦ Table of Contents

Front Matter ....Pages i-v
History of the Research on the Glucose Receptor (Willy J. Malaisse)....Pages 1-28
Cell-Surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic β-Cells (Yuko Nakagawa, Hatsumi Niki)....Pages 29-35
KATP Channel-Independent Pathway and the Glucoreceptor (Toru Aizawa, Mitsuhisa Komatsu)....Pages 37-49
Signaling System Activated by the Glucose-Sensing Receptor (Johan Medina, Yuko Nakagawa)....Pages 51-59
The Role of the Glucose-Sensing Receptor in Glucose-Induced Insulin Secretion in Pancreatic β-Cells (Yuko Nakagawa, Johan Medina)....Pages 61-71

✦ Subjects

Biomedicine; Human Physiology; Endocrinology