Glucose Responsive Hydrogel Networks Based on Protein Recognition

✍ Scribed by Jason D. Ehrick; Matthew R. Luckett; Santoshkumar Khatwani; Yinan Wei; Sapna K. Deo; Leonidas G. Bachas; Sylvia Daunert

• Book ID: 102473826
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 305 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200800337

✦ Synopsis

Abstract

Stimuli‐responsive materials capable of manifesting physical changes in response to environmental signals are valuable tools for use in a variety of biomedical applications. Herein we describe one such smart glucose‐responsive hydrogel material prepared by immobilizing the glucose/galactose binding protein within an acrylamide hydrogel network. This hydrogel demonstrates a quantitative “accordion”‐like dynamic response in the presence of glucose. We further show the feasibility of employing this responsive smart material as a gating agent for controlled drug delivery, thus, demonstrating that these hydrogels may eventually lead to the development of implantable drug delivery systems for diabetes management applications.

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