Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

✍ Scribed by Anthony K. Ogawa; Chris A. Willoughby; Raynald Bergeron; Kenneth P. Ellsworth; Wayne M. Geissler; Robert W. Myers; Jun Yao; Georgianna Harris; Kevin T. Chapman

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 169 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00798-4

✦ Synopsis

The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented. SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.