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Glucose-induced insulin secretion is potentiated by a new imidazoline compound

✍ Scribed by Hans-Jürgen Mest; Achim Raap; Jürgen Schloos; Iris Treinies; Michael Paal; Ulrich Giese; Veikko Koivisto

Publisher: Springer-Verlag
Year: 2001
Tongue: English
Weight: 86 KB
Volume: 364
Category: Article
ISSN: 0028-1298
DOI: 10.1007/s002100100415

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## Abstract Insulin‐dependent diabetes mellitus (IDDM) is an autoimmune disease that is characterized by selective destruction of insulin secreting pancreatic islets β‐cells. The formation of cytokines (IL‐1β, IL‐6, TNF‐α, etc.) leads to extensive morphological damage of β‐cells, DNA fragmentation,