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Glucose Controls CREB Activity in Islet Cells via Regulated Phosphorylation of TORC2.

✍ Scribed by Jansson, Deidre; NG, Andy Cheuk-Him; Fu, Accalia; Depatie, Chantal; Screaton, Robert A.

Book ID
122697096
Publisher
Canadian Diabetes Association
Year
2008
Tongue
English
Weight
784 KB
Volume
32
Category
Article
ISSN
1499-2671

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## Abstract Diabetic nephropathy manifests aberrant activation of TORC1, which senses key signals to modulate protein synthesis and renal hypertrophy. PRAS40 has recently been identified as a raptor‐interacting protein and is a component and a constitutive inhibitor of TORC1. The mechanism by which