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Glucosamine synthetase from Escherichia coli: kinetic mechanism and inhibition by N3-fumaroyl-L-2,3-diaminopropionic derivatives

โœ Scribed by Badet, Bernard; Vermoote, Patricia; Le Goffic, Francois


Book ID
125967376
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
802 KB
Volume
27
Category
Article
ISSN
0006-2960

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Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the enzyme by the Michael addition of the S-H group to the FMDP molecule followed by cyclisatio