Glucosamine Hydrochloride Functionalized Water-Soluble Conjugated Polyfluorene: Synthesis, Characterization, and Interactions with DNA

✍ Scribed by Qi Chen; Qian-Yi Cheng; Yan-Chao Zhao; Bao-Hang Han

• Book ID: 102493607
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 318 KB
• Volume: 30
• Category: Article
• ISSN: 1022-1336
• DOI: 10.1002/marc.200900226

✦ Synopsis

Abstract

Novel glucosamine hydrochloride functionalized water‐soluble conjugated polyfluorene was easily synthesized through Cu(I)‐catalyzed azide/alkyne “click” ligation and Suzuki coupling polymerization. The water‐solubility and biocompatibility of the polymer were improved after grafting glucosamine hydrochloride to the side chains of the conjugated polymer. As a fluorescent model system of chitosan, its interaction with single‐stranded DNA was studied by spectrofluorometric titration.

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