Glucosamine Decreases Inflammatory Gene Expression in Intervertebral Disc Cells Exposed to Inflammatory or Mechanical Stress

Interleukin-17 synergizes with IFNγ or T

Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

✍ Mostafa A. Gabr; Liufang Jing; Antonia R. Helbling; S. Michael Sinclair; Kyle D. 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 199 KB

## Abstract Interleukin‐17 (IL‐17) is a cytokine recently shown to be elevated, along with interferon‐γ (IFNγ) and tumor necrosis factor (TNFα), in degenerated and herniated intervertebral disc (IVD) tissues, suggesting a role for these cytokines in intervertebral disc disease. The objective of our