Glucocorticoids stimulate the activity of large-conductance Ca2+-activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism

Potent stimulation of large-conductance

Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-δ, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells

✍ Sheng-Nan Wu; Ya-Jean Wang; Ming-Wei Lin 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 426 KB 👁 1 views

## Abstract The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3–100 µM) increased the amplitude of Ca^2+^‐activated K^+^ current (I~K(Ca)~) in a concentration‐dependent manner with an EC~50~