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Glucocorticoids Regulate Hippocampal 11β-Hydroxysteroid Dehydrogenase Activity and Gene Expression in vivo in the Rat

✍ Scribed by Susan C. Low; Marie-Pierre Moisan; June M. Noble; Christopher R. W. Edwards; Jonathan R. Seckl


Book ID
108869324
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
961 KB
Volume
6
Category
Article
ISSN
0953-8194

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Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11beta-Hydroxysteroid dehydrogenase-1 (11beta-HSD1) is expressed in glucocorticoid target tis