Glucocorticoids, phospholipase A2 and inflammation
โ Scribed by Rod Flower
- Book ID
- 119110661
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 445 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0165-6147
No coin nor oath required. For personal study only.
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Phospholipase A2 (PLA2) plays a key role in the production of proinflammatory mediators, namely the arachidonic acid-derived eicosanoids, lysophospholipids, and platelet-activating factor, and indirectly influences the generation of cytokines, nitric oxide (NO), and free radicals. Accordingly, regul
Phospholipase A2 (PLA2) is known to play an important intracellular role in inflammatory processes but does it also perform a vital function extracellularly? Here, W. Pruzanski and P. Vadas marshall the evidence supporting PLA2 as a mediator of inflammation, specifically in linking local and systemi