𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Glucocorticoids modulate rat hypothalamic corticotrophin-releasing factor release induced by interleukin-1

✍ Scribed by J. C. Cambronero; José Borrell; Dr. C. Guaza


Book ID
102909544
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
594 KB
Volume
24
Category
Article
ISSN
0360-4012

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✦ Synopsis


Continuous in vitro perifusion of rat hypothalami with interleukin-1 beta (IL-1) increased corticotropin-releasing factor (CRF) secretion in a dose-dependent manner, in the range of 1 to 5 U/ml. The stimulatory action of IL-1 was significantly attenuated by dexamethasone, both by addition to the perifusion medium and by in vivo dexamethasone pretreatment. The data suggest that an immunoneuroendocrine interaction circuit, subjected to glucocorticoid negative feedback, has an essential role in maintaining organism homeostasis.


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