✦ LIBER ✦

Glucocorticoids, lipocortins and the immune response

✍ Scribed by Nicolas J. Goulding; Paul M. Guyre

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 743 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90089-b

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✦ Synopsis

Clucocorticoids

are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-I, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation.

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