Glucocorticoids in T cell apoptosis and function
β Scribed by M. J. Herold; K. G. McPherson; H. M. Reichardt
- Book ID
- 105758214
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 921 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Exogenous glucocorticoid hormones are widely used as therapeutical agents, whereas endogenous glucocorticoids may act as physiological immunosuppressants involved in the control of immune and inflammatory responses. The optimal activation of T lymphocytes requires two distinct signals:
The application of glucocorticoids (GC') in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.RI-R5, isolated from the GC-sensitive human acute-1-cell-leukemic line,