✦ LIBER ✦

Glucocorticoids and immunosup pressants do not change the prevalence of necrosis and regeneration in mdx skeletal muscles

✍ Scribed by MD Boaz Weller; MD Roberto Massa; MD George Karpati; MD Stirling Carpenter

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 334 KB
Volume: 14
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880140812

No coin nor oath required. For personal study only.

✦ Synopsis

Therapeutic doses of methylprednisolone, azathioprine, cyclosporin A, and cyclophosphamide administered to mdx mice between 15 and 45 days of age failed to significantly influence the time course and prevalence of necrosis and regeneration or serum creatine kinase activity. This finding contrasts with previously reported findings of beneficial effects of glucocorticoids in Duchenne muscular dystrophy (DMD). This may indicate that, mechanisms upon which beneficial effects of glucocorticoids depend in DMD, do not operate (sufficiently) in mdx mice.