Glucocorticoid–dextran conjugates as potential prodrugs for colon-specific delivery: Hydrolysis in rat gastrointestinal tract contents

Glucocorticoid-dextran conjugates as pot

Glucocorticoid-dextran conjugates as potential prodrugs for colonspecific delivery: Steady-state pharmacokinetics in the rat

✍ Andrew D. McLeod; Lorna Tolentino; Dr Thomas N. Tozer 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 630 KB

Chronic colitis, e.g., ulcerative colitis and Crohn's disease, is presently treated with glucocorticoids and other antiinflammatory agents. Side-effects limit chronic glucocorticoid therapy. The dose, and consequently the side-effects, may be reduced by using prodrugs that selectively deliver drug t