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Glucocorticoid regulation of rRNA synthesis

✍ Scribed by Pramod B. Mahajan; E. Aubrey Thompson

Publisher
Springer
Year
1991
Tongue
English
Weight
413 KB
Volume
104
Category
Article
ISSN
0300-8177

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✦ Synopsis

Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I. The data indicate that TFIC is a bona fide initiation factor that is required for formation of the first phosphodiester bond of nascent pre-rRNA. Extracts from dexamethasone-treated cells are devoid of this factor and cannot form initiated complexes in vitro.

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