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Glucocorticoid receptor-mediated reduction of IgG-fusion protein aggregation in Chinese hamster ovary cells

✍ Scribed by Yueming Qian; Ying Jing; Zheng Jian Li


Publisher
American Institute of Chemical Engineers
Year
2010
Tongue
English
Weight
295 KB
Volume
26
Category
Article
ISSN
8756-7938

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Sialylation enhancement of CTLA4-Ig fusi
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## Abstract The importance of glycoprotein sialic acid levels is well known, as increased levels have been shown to increase in vivo serum half‐life profiles. Here we demonstrate for the first time that dexamethasone (DEX) was capable of improving the sialylation of a CTLA4‐Ig fusion protein produc