𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Glucocorticoid induction of proline oxidase in LLC-RK1 cells

✍ Scribed by Edward M. Kowaloff; Dr. James M. Phang; Alnora S. Granger; Sylvia J. Downing

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
508 KB
Volume
97
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Dexamethasone induced proline oxidase in cultured LLC‐RK1 cells, an epithelial cell line derived from rabbit kidney. The dexamethasone‐mediated increase in enzyme activity was concentration and time dependent. Although the effect could be dissociated from cell growth and cell density, it was dependent on protein and RNA synthesis. A comparison of the enzyme isolated from control and dexamethasone‐treated cells showed that the increased activity was not due to an alteration in the affinity of the enzyme for proline. These findings suggest that glucocorticoids induce the synthesis of proline oxidase in mammalian cells.

📜 SIMILAR VOLUMES

Glucocorticoid hormone receptor mediated
Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells
✍ Michael Karin; Harvey R. Herschman 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

## Abstract HeLa cells grown in chemically defined medium lacking glucocorticoids synthesize metallothioneins, low molecular‐weight heavy‐metal binding proteins. Dexamethasone and hydrocortisone increase the rate of metal‐lothionein synthesis five‐ to ten‐fold. Maximal induction is achieved with 10

Glucocorticoid binding and mechanism of
Glucocorticoid binding and mechanism of resistance in some clones of mouse myeloid leukemic cells resistant to induction of differentiation by dexamethasone
✍ Yoshio Honma; Takashi Kasukabe; Junko Okabe; Motoo Hozumi 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

## Abstract Several clones of dexamethasone‐resistant cells, which could not differentiate even in a high concentration of dexamethasone, were isolated from glucocorticoid‐sensitive myeloid leukemic cells. Some of them were shown to be deficient in steroid binding to specific cytoplasmic receptors,

Suppression of proline-directed protein
Suppression of proline-directed protein kinase FA potentiates apoptotic induction and greatly enhances chemosensitivity in human acute lymphoblastic leukemia cells
✍ Chih-Ping Hsu; Chuan-Ching Yang; Sheng-Fen Hsueh M.S.; Chien-Chung Peng B.S.; Hs 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 1 views

## BACKGROUND. Previously, the authors reported that specific antisense suppression of overexpressed proline-directed protein kinase (PDPK) F A enhances the chemosensitivity of various clinical anticancer drugs up to Ͼ 100-fold in human prostate carcinoma cells, suggesting an association of PDPK F

Induction or suppression of expression o
Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin β 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expression
✍ Yanbo Sun; Hong Lin; Yunfeng Zhu; Cuiling Ma; Jianping Ye; Jia Luo 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB 👁 1 views

## Abstract The ErbB family of receptor kinases is composed of four members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. Amplification of the ErbB2/neu is found in about 30% of breast cancer patients and is associated with a poor prognosis. Heregulin (HRG) activates