Glucocorticoid-induced cortical bone loss is mediated by osteoblast-controlled activation of bone resorption
β Scribed by M. Herrmann; H. Henneicke; J. Street; J. Modzelewski; R. Kalak; F. Buttgereit; C.R. Dunstan; H. Zhou; M.J. Seibel
- Book ID
- 116321174
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 163 KB
- Volume
- 44
- Category
- Article
- ISSN
- 8756-3282
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have previously shown that p38 mitogen-activated protein kinase (MAPK) inhibitors, which block the production and action of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin-1 (IL-1), are effective in models of bone and cartilage degradation. To further investigate the ro
## Abstract The Runx2 gene is essential for osteoblast differentiation and function. In vivo overβexpression of Runx2 in osteoblasts increases bone resorption, and blocks terminal osteoblast differentiation. Several lines of evidence suggest that osteoblastic matrix metalloproteinases (MMPs) could