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Glucocortcoids mediate the stress-induced extracellular accumulation of glutamate

✍ Scribed by Bita Moghaddam; Maria L. Bolinao; Becky Stein-Behrens; Robert Sapolsky

Book ID
115805180
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
378 KB
Volume
655
Category
Article
ISSN
0006-8993

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## Abstract The glutamate uptake inhibitor L‐__trans__‐2,4‐pyrrolidine‐dicarboxylate (PDC) induces glutamate accumulation and neuronal damage in cultured cells. We have used dissociated cortical cells in culture to study whether the toxicity induced by inhibiting glutamate uptake with PDC could be