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Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism

✍ Scribed by Michael J. Eblan; Sonja Scholz; Barbara Stubblefield; Usha Gutti; Ozlem Goker-Alpan; Kathleen S. Hruska; Andrew B. Singleton; Ellen Sidransky


Book ID
116768767
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
73 KB
Volume
404
Category
Article
ISSN
0304-3940

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LRRK2 G2019S mutations are associated wi
✍ Rachel Saunders-Pullman; Matthew J. Barrett; Kaili M. Stanley; Marta San Luciano πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 70 KB

## Abstract Leucine rich repeat kinase (__LRRK2__) G2019S mutations are presumed to cause PD through a toxic gain of function of the protein kinase. Small molecule kinase inhibitors have been developed for the treatment of certain cancers, and some antioncogenic agents such as sunitinib, may nonspe