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Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

โœ Scribed by Michael W.J. Cleeter; Kai-Yin Chau; Caroline Gluck; Atul Mehta; Derralynn A. Hughes; Michael Duchen; Nicholas William Wood; John Hardy; J. Mark Cooper; Anthony Henry Schapira

Book ID
118488013
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
647 KB
Volume
62
Category
Article
ISSN
0197-0186

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Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially degenerate in Huntington's disease, with the presence