Glucagon antagonists : Synthesis and inhibitory properties of Asp3-containing glucagon analogs
β Scribed by David ANDREU; Robert B. MERRIFIELD
- Book ID
- 115125075
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 707 KB
- Volume
- 164
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Somatostatin (SS) and two glucagon selective analogs [DβCys^l4^]βSS and [DβTrp^8^, DβCys^14^]βSS have been synthesized in gram quantities by the solidβphase procedure. A general modification of Monahan and Gilon's procedure for esterification of the first protected amino acid onto the c
A novel class of 1,3,5-pyrazoles has been discovered as potent human glucagon receptor antagonists. Notably, compound 26 is orally bioavailable in several preclinical species and shows selectivity towards cardiac ion channels, other family B receptors such hGIP and hGLP1, and a large panel of enzyme